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. 2021 Oct 22;6(20):e151078. doi: 10.1172/jci.insight.151078

Figure 8. Absence of the Meibomian gland in mice lacking both Krox20 and Krox24.

Figure 8

(A) Gross images of the eye in Krox20fl/fl (WT), Krox24–/– (Krox24-KO), Krox20fl/fl;K14-Cre (Krox20-cKO), and Krox24–/–;Krox20fl/fl;K14-Cre (DKO) mice. (B–F) Histological analyses revealed the absence of the Meibomian gland (MG) in the eyelids of Krox20-cKO and DKO mice, whereas Krox24-KO and WT littermates maintained normal MG structure. Gross images in A are the same as those in Figure 7A, Supplemental Figure 1 (8M), and Supplemental Figure 2A. Dashed lines (red in B and white in C–F) demarcate the Meibomian gland in the control mice and its expected location of the Meibomian glands in the KOs. n = 20 mice for each genotype. Representative images are shown. Scale bar: 100 μm.