Figure 2. TRAM deficiency reduces monocyte inflammatory state in atherosclerotic mice.

Apoe^−/− Tram^+/+ mice and Apoe^−/− Tram^−/− mice were fed with HFD for 8 weeks. Surface expressions of CCR2 and SIRP-α on CD11b⁺Ly6C⁺⁺ monocytes in the peripheral blood (A), BM (B), spleen (C), and aorta (D) were examined by flow cytometry. Data are representative of 2 independent experiments, and error bars represent means ± SEM. *P < 0.05, **P < 0.01, and ***P < 0.001; Student’s 2-tailed t test (n = 5 to 10 for each group).