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. 2021 Oct 22;6(20):e145256. doi: 10.1172/jci.insight.145256

Figure 7. NPHP5 localization in WT and in Cep290 mutants.

Figure 7

NPHP5 antibody signal localizes to the base of the CC and the region on the rootlet and BB in WT and in Cep290 mutant animals before photoreceptor degeneration. Confocal images of P10 WT (A), rd16 (B), NN (C), and KO (D) cilia with separated channels at low magnification to the right. WT image acquisition and processing settings were applied to WT, rd16, NN, and KO data. Scale bar: 10 μm. AcTub, acetylated α-tubulin; CC, connecting cilium; WT, wild-type; rd16, Cep290rd16; nn, near null-Cep290tm1.1Jgg; ko, Cep290-knockout.