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. 2021 Oct 22;6(20):e145256. doi: 10.1172/jci.insight.145256

Figure 9. Y-links are present in P10 Cep290 mutant CC.

Figure 9

TEM longitudinal images of P10 photoreceptor cilia from (A) WT, (B) Rd16, (C) NN, and (D) KO animals depicting the (A) properly developed CC and OS, (B) rudimentary OS, and (C and D) rudimentary CC. CC (yellow arrow) and OS discs (yellow asterisk) are highlighted. Scale bar: 2 μm. (E–H) Cross section images through the CC of (E) WT, (F) Rd16, (G) NN, and (H) KO animals. Y-links (yellow box) are visible in WT and Cep290 mutants. Scale bar: 100 nm. Insets highlight Y-links within the box. Scale bar: 20 nm. Lower magnification views of the same regions of these retinas are shown in Supplemental Figure 6. (I) Cross sections through distal ends of the CC showing abnormal structures in KO retinas. See also Supplemental Figure 5B. (J) Dot plot with averages and SEMs of measurements of annotated areas within CC sections from WT (43 cilia from 2 animals), Rd16 (29 cilia from 3 animals), NN (58 cilia from 2 animals), and KO (44 cilia from 2 animals). Measurements were compared using 1-way ANOVA with Dunnett’s test.