Figure 1. β-Hydroxybutyrate biosynthesis is autophagy dependent.

β-Hydroxybutyrate (βHB) was measured in serum samples from nonfasted (free access to food) and fasted (24 hours) Dahl S (A) and Dahl R (B) rats (both low-salt diet fed), pretreated with and without lysosome acidification inhibitor chloroquine (2 × 50 mg/kg) or AMPKα inhibitor dorsomorphin (25 mg/kg). Mean ± SEM. n = 5–10. Two-way ANOVA: *P < 0.05, ****P < 0.0001.