Table 3.
Binding interactions are classified based on sequence identity and interactions.
| Mammals | Experimental results | Sequence identity | Interaction energy |
|---|---|---|---|
| Human | High [1,21,46,47] | High | High |
| Bovine | Medium [37] | High (11/13) | High |
| Sheep | Medium [37] | High (11/13) | Medium |
| Cat | High [9,10,37,48] | Medium (9/13) | High |
| Tiger | Medium [12] | Medium (9/13) | Medium |
| Panda | Not available | Medium (9/13) | High |
| Pig | Medium [37,38] | Medium (9/13) | Low |
| Rabbit | Low [48] | Medium (9/13) | Medium |
| Dog | Medium [11,41] | Medium (8/13) | Medium |
| Horse | Medium [37] | Medium (8/13) | Low |
| Pangolin | Medium [48] | Medium (7/13) | Medium |
| Bat (LH) | Not susceptible [37] | Medium (7/13) | Low |
| Bat (CH) | Not susceptible [37] | Medium (7/13) | Medium |
| Civet | Not susceptible [48] | Low (6/13) | Low |
| Mouse | Not susceptible [8,44,48] | Low (6/13) | Low |
| Rat | Not susceptible [48] | Low (6/13) | Low |
Classification criteria: Sequence identity of 13 residues compared to hACE2 (Low, 0–50%; Medium, 50–75%; High, 75%–100%); Interaction energy (Low, −100 ∼ −130 kcal/mol; Medium, −130 ∼ −160 kcal/mol; and High, −160 ∼ −190 kcal/mol).