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. 2021 Oct 18;12:750145. doi: 10.3389/fendo.2021.750145

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Copyright © 2021 Faure, Khoueiry, Quanico, Acloque, Guerquin, Bertoldo, Chevaleyre, Ramé, Fournier, Salzet, Dupont and Froment

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of metformin in embryo by selected ion monitoring (SIM) mass spectrometry (MS). (A) Upper panel, picture with brightness and artificial color of sagittal section of a mouse embryo (15dpc) from a metformin-treated mother. Lower panel, MS imaging of metformin signal (m/z 130.1), images acquired at 30 μm spatial resolution. Intensity bar to the left of the picture. Scale bar 1 cm. (B) Embryonic testis (15dpc) and (C) neonatal testis (1dpp) exposed to metformin in utero. Panel 1: picture with brightness. Panel 2 pictures showing metformin signal (m/z 130.1). Panel 3 and 4 pictures showing positive signal (lipids) (m/z 830.4 and 844.4). Intensity values are expressed in arbitrary units (a.u.) normalized against the total ion count (low intensity: blue staining, high intensity: red staining), the intensity bar is in the middle of the image panel. We can note an absence of metformin on the testis. Scale bar 1 mm.