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. 2021 Oct 24;12(11):1840–1846. doi: 10.1021/acsmedchemlett.1c00481

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© 2021 American Chemical Society

This article is made available via the ACS COVID-19 subset for unrestricted RESEARCH re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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NK007(S,R) and remdesivir (RDV) inhibit virus replication in lungs of COVID-19 hamster rats. (A) Schematic diagram of NK007(S,R) or remdesivir treated COVID-19 hamster rats. (B) Weight loss of infected rats treated with NK007 or remdesivir. (C) Viral RNA copies in rat lungs at day 4 (unpaired t test). (D) Histological scores of lung inflammation of NK007(S,R) or remdesivir treated SARS-CoV-2 infected rats (unpaired t test). (E) Representative hematoxylin-eosin (HE) staining of lungs from rats harvested at day 4. Bar: 100 μm.