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. 2021 Oct 4;49(19):11224–11240. doi: 10.1093/nar/gkab842

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© The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — USP37 expression positively correlates with BLM levels in breast cancer tissues. (A, B) USP37 expression in normal tissue and breast carcinoma (Oncomine data). (C) GEO database showing the survival of breast cancer patients with low (n = 112) and high (n = 127) expression of USP37. Statistical analysis with the two-sided log-rank (Mantel-Cox) test revealed statistically significant differences as shown on the graph. (D) Representative images of immunohistochemical staining of USP37 and BLM in normal and breast carcinoma. Scale bars, 200 μm. (E) Quantification of USP37 and BLM protein levels in normal and breast carcinoma. (F) Correlation study of USP37 and BLM in breast carcinoma. Statistical analyses were performed with the χ² test. R: the Pearson correlation coefficient.