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. 2021 Oct 11;49(19):11022–11037. doi: 10.1093/nar/gkab882

Figure 9.

Figure 9.

Model of UPF1 phosphorylation by AKT1. UPF3X is loaded on mRNP by the exon junction complex (EJC). UPF3X would recruit AKT1 before recruiting UPF1 and phosphorylating it. These events occur before or during the pioneer round of translation, since the cap structure is bound by CBP80 and not eIF4E.