Table 4.
Associations between heritable risk factors and diabetes by the healthy lifestyle score in participants from two communities
| Community | Healthy lifestyle score | P for interaction | ||
|---|---|---|---|---|
| Low | Intermediate | High | ||
| Songnan | ||||
| Genetic risk score per 10‐point increment | ||||
| Model 1 † | 2.02 (1.60−2.56) | 1.78 (1.39−2.28) | 2.35 (1.67−3.32) | 0.67 |
| Model 2 ‡ | 2.05 (1.61−2.60) | 1.81 (1.41−2.32) | 2.39 (1.68−3.41) | 0.70 |
| Family history | ||||
| Model 1 † | 2.32 (1.82−2.96) | 2.92 (2.26−3.79) | 3.01 (2.18−4.16) | 0.52 |
| Model 2 ‡ | 2.36 (1.85−3.02) | 3.05 (2.34−3.97) | 3.06 (2.20−4.27) | 0.46 |
| Youyi | ||||
| Genetic risk score per 10‐point increment | ||||
| Model 1 † | 2.18 (1.59−2.99) | 2.43 (1.74−3.39) | 2.22 (1.44−3.41) | 0.98 |
| Model 2 ‡ | 2.21 (1.61−3.04) | 2.48 (1.78−3.48) | 2.11 (1.37−3.26) | 0.93 |
| Family history | ||||
| Model 1 † | 3.95 (2.91−5.37) | 3.33 (2.42−4.59) | 3.48 (2.32−5.21) | 0.22 |
| Model 2 ‡ | 4.01 (2.94−5.47) | 3.34 (2.42−4.61) | 3.75 (2.48−5.66) | 0.30 |
| Pooled results | ||||
| Genetic risk score per 10‐point increment | ||||
| Model 1 † | 2.08 (1.72−2.51) | 1.99 (1.63−2.42) | 2.30 (1.76−3.01) | 0.93 |
| Model 2 ‡ | 2.10 (1.74−2.54) | 2.03 (1.66−2.47) | 2.28 (1.73−2.99) | 0.93 |
| Family history | ||||
| Model 1 † | 2.85 (2.36−3.45) | 3.08 (2.52−3.77) | 3.19 (2.47−4.10) | 0.37 |
| Model 2 ‡ | 2.90 (2.39−3.52) | 3.17 (2.58−3.88) | 3.32 (2.56−4.29) | 0.41 |
†
Model 1 was adjusted for age and sex.
‡
Model 2 was adjusted for age, sex, education attainment (less than high school, high school or further education), hypertension (yes, no) and dyslipidemia (yes, no).