FIGURE 2.

Tissue factor (TF) expression correlates with fibrin and platelet factor 4 (PF4) expression. A, Quantification of fibrin‐ and PF4‐positive thrombi images from confocal immunofluorescent in coronavirus disease 19 (COVID‐19)‐acute respiratory distress syndrome (ARDS; n = 11) and non‐‐COVID‐19 ARDS (n = 6) and pathologically normal control (n = 11) lungs tissues using Imaris and ImageJ software. B, Linear correlations of TF with fibrin (R² = .52; P < .002) and TF with PF4 (R² = .63; P = .001). C, Schematic diagram depicts potential mechanism by which severe acute respiratory syndrome coronavirus 2 infection in the lungs can increase TF expression, which might cause thrombi formation, by initiating fibrin formation and platelet activation