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Timeline for evaluation of drug efficacy. A, Condition in which mechanical ventilation was completed within 24 hr after the commencement of infusion, and (B) condition in which mechanical ventilation lasted for longer than 24 hr after the commencement of infusion. Arrowheads represent times of blood sampling for pharmacokinetic measurements. The asterisk indicates the period of efficacy evaluation for the primary endpoint. DEX = dexmedetomidine.
