Figure 9.

Schematic representation of nuclear IL-33 roles in glioma cells. Nuclear IL-33 interacts with H2A and is associated with chromatins in glioma cells. Declined expression of nuclear IL-33 (IL33KD) increases glioma cell sensitization to DNA damaging drugs and attenuates cancerous nuclear characteristics. In contrast, nuclear IL-33 highly expressed in glioma cells (IL33oe) increases DNA repair capability in glioma cells to induce resistance to the action of DNA damaging drugs and promotes the abnormality of cancerous nuclear structure, such as the formation of multiple nuclear lobes. IL-33, interleukin-33; IL33oe, IL-33 overexpression.