Table 2.
Frequency of presenting symptoms, signs, and investigations of ILBCL from varying cohorts
| Cohort and date | Murase et al5 | Shimada et al3 4 | Matsue et al2 | Ferreri et al16 | Ferreri et al6 |
| Year | 2007 | 2008–09 | 2019 | 2004 | 2007 |
| Population no | 96 | 106 | 42 | 38 | 50 |
| Median age | 67 | 67 | 73 | 70 | 68 |
| Male (%) | 52 | 56 | 52.4 | 45 | 46 |
| Symptoms (%) | |||||
| Constitutional (Fever, night sweats, weight loss, fatigue) | 76 | 84 | 98 | 55 | 22–42 |
| Neurological (dementia, cerebrovascular events, peripheral neuropathy) | 27 | 25 | 45 | 34 | 42 |
| Respiratory (dyspnoea, hypoxaemia / hypoxia, pulmonary involvement) | 34 | 33 | 80 (hypoxia only) | 3 | 18 |
| Signs (%) | |||||
| Cutaneous (nodules, plaques, macules, telangiectasia, oedema, pain) | 15 | 17 | 14 | 39 | 38 |
| Spleen | 67 | 65 | 81 | 26 | 26 |
| Liver | 55 | 48 | – | 26 | 26 |
| Lymph node involvement | 11 | – | – | 11 | 8 |
| Investigations (%) | |||||
| Bone marrow (haemophagocytosis, atypical lymphoid cells, histiocytosis) | 75 | 59 | 60 | 32 | 30 |
| Haemoglobin <110–120 g/L | 66 | 68 | 95 | 63 (<120) | 66 |
| White cells count <4.0×109/L | 27 | 27 | 24 | 22 | |
| Platelets <100–150×109/L | 58 | 58 | 69 | 29 (<150) | 32 |
| Albumin <30–36 g/L | 47 | 61 | 86 | 18 (<36) | – |
| Elevated Lactate Dehydrogenase (greater than upper limit of normal) | 93 | 98 | 100 (median—934 units/L) | 86 | 85 |
| Elevated Soluble Interluekin-2 Receptor (>5000 U/mL) | 56 | 66 | 69 (median—6886 units/mL) | – | – |
| Blood film: atypical lymphoid cells | 24 | 34 | 14 | 5 | 4 |
ILBCL, intravascular large B-cell lymphoma.