Table 1: Dose comparison between TBI and TMI planning for a prescribed dose of 11 Gy.

A) The mean delivered dose to target (bone marrow, spleen) and organs (lungs, gut and liver) was determined for the TBI, TMI I and TMI I+4 treatment plans. The % reduction in dose delivered was calculated using the TBI-delivered dose to the respective organs as reference. There was a significant reduction of dose delivered to lung, liver and gut; however, dose delivered to bone marrow was similar between TBI, TMI I and TMI I+4 plans. B-D)The D95 (B), D80 (C), and D5 (D) for bones and other vital organs for TBI, TMI I and TMI I+4 plans. The dose values ± s.d was calculated for n=5 mice/group.

A)
Organ	TBI	TMI I		TMI I + 4Gy
	Dmean (Gy)	Dmean (Gy)	% Dose difference from TBI	Dmean (Gy)	% Dose difference from TBI
Bone (PTV)	27.5 ± 1.2	27.8 ± 1.6	1.1	26.5 ± 1.5	−3.6
Lungs	12.0 ± 0.7	5.1 ± 0.9	−57.5	7.5 ± 0.8	−37.5
Gut	11.5 ± 0.1	3.8 ± 0.9	−67.0	5.4 ± 0.1	−53.1
Liver	12.6 ± 0.2	4.4 ± 0.5	−65.1	6.0 ± 0.8	−52.4
B)
Organ	TBI	TMI I		TM I + 4Gy
	D95 (Gy)	D95 (Gy)	% Dose difference from TBI	D95 (Gy)	% Dose difference from TBI
Bone (PTV)	1.4 ± 0.7	2.6 ± 3.4	85.7	7.6 ± 3.7	442.8
Lungs	8.8 ± 0.4	1.0 ± 0.1	−88.6	4.1 ± 0.3	−60.0
Gut	8.6 ± 0.1	0.7 ± 0.1	−91.9	3.5 ± 0.1	−59.5
Liver	9.4 ± 0.1	0.9 ± 0.1	−90.4	4.3 ± 0.1	−53.8
C)
Organ	TBI	TMI I		TMI I + 4Gy
	D80 (Gy)	D80 (Gy)	% Dose difference from TBI	D80 (Gy)	% Dose difference from TBI
Bone (PTV)	15.2 ± 3.1	19.6 ± 5.8	28.9	18.6 ± 4.3	22.4
Lungs	10.2 ± 0.5	1.5 ± 0.3	−85.3	4.5 ± 0.2	−55.9
Gut	10.0 ± 0.1	0.9 ± 0.1	−91.0	3.9 ± 0.2	−61.0
Liver	10.8 ± 0.1	1.3 ± 0.1	−88.0	4.4 ± 0.2	−58.3
D)
Organ	TBI	TMI I		TMI I + 4Gy
	D5 (Gy)	D5 (Gy)	% Dose difference from TBI	D5 (Gy)	% Dose difference from TBI
Bone (PTV)	40.2 ± 1.1	40.7 ± 2.9	1.2	37.1 ± 5.2	−7.7
Lungs	15.7 ± 1.3	11.3 ± 0.6	−28.0	11.1 ± 0.7	−29.3
Gut	14.6 ± 0.1	10.8 ± 0.9	−26.0	10.7 ± 0.2	−26.7
Liver	17.6 ± 1.3	11.3 ± 1.4	−35.8	10.1 ± 0.6	−42.6