Fig 11. Summary of efforts to develop immunofocusing trimers.

The 17 strains are partitioned into groups 1 and 2. The effects of modifications on expression, infectivity and sensitivity to V2 and/or V3 MAbs are indicated. Desired features are depicted in green boxes. Unwanted features are depicted in red boxes. Features of selected clones are shown in the lower rows along with their V3-sensitivities and potential use in vaccine regimens. Asterisks indicate modifications that were made in combination with others, so any effects observed cannot be unambiguously linked to any one modification.