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. 2021 Jun 23;12:600210. doi: 10.3389/fgene.2021.600210

FIGURE 3.

FIGURE 3

(A) The logMAR BCVA of male patients with variants in exon1-14 and ORF15 showed that patients with variants in exon1-14 have a better visual acuity. (B) Patients with variants in RCC1-like domain were no significant difference compared to those in ORF15. (C) Comparison of logMAR BCVA between M + I and T, there was no significant difference in variation type. (D) ROC curves suggested that our model shows high sensitivity and specificity in distinguishing different degrees of BCVA. The datasets used for AUC analysis were from available males’ data and were randomly divided into two independent datasets (training and test datasets) by the R-software. BCVA, best corrected visual acuity; E1-14, exon1-exon14; RCC1, RCC1-like domain; M + I, missense and in-frame; T, truncation. ns, no statistical significance; ∗∗, P value less than 0.01.