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Binding affinities of bemarituzumab and FPA144-F to human FcγRIIIa (V158)
| Antibody | KD (Koff/Kon) (nM) |
|---|---|
| FPA144-A (bemarituzumab) | 9.2 |
| FPA144-F (the fucosylated version) | 207 |
Kon = associate constant; Koff = dissociate constant; KD = equilibrium dissociation constant.
Surface plasmon resonance was used to determine binding affinities; 5 concentrations (0–1000 nM) of FcγRIIIa (V158) were tested. Kon, Koff, and KD were calculated using the Biacore T100 Evaluation Software 1:1 binding model.
