Figure 1.

Circ_0004018 is obviously down-regulated in HCC cells. (a) Down-regulation of circ_0004018 in HCC was demonstrated in circRNADisease database. (b). Measurement of circ_0004018 expression in different cell lines was performed via RT-qPCR. (c). RNA levels of circ_0004018 and linear-SMYD4 were detected after RNase R treatment in SNU-182 and SK-HEP-1. (d). AGE was conducted to test the expression of circ_0004018. (e). ActD was added to examine the stability of circ_0004018 and linear-SMYD4 in SNU-182 and SK-HEP-1 cells. *P < 0.05, **P < 0.01