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. 2021 Oct 29;10(1):1995166. doi: 10.1080/2162402X.2021.1995166

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Diagnostic and prognostic value of PD-L1-CD63 signal measured by SiMoa in patients with DLBCL. (a-c). Characterization of isolated exosomes by transmission electron microscopy (TEM) (a), size distribution (b) and western blots (c). (d-e) Qualification of PD-L1+ EVs in DLBCL patients and healthy subjects by western blot and SiMoa. (f) The PD-L1-CD63 signal in DLBCL and healthy subjects measured by SiMoa. (g) ROC analysis to evaluate the diagnostic power to differentiate DLBCL cases (n = 164) from the healthy controls with PD-L1-CD63 assay. (h, i) The association of PD-L1-CD63 signal with the number of extranodal sites, tumor mass and CR status after treatment. (j, k) The progression-free survival (PFS) and overall survival (OS) in high and low PD-L1-CD63 signal group