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. 2021 Sep 8;20(20):2174–2194. doi: 10.1080/15384101.2021.1974787

Figure 2.

Figure 2.

Effect of silencing TrkA (shTrkA) and silencing TrkB (shTrkB) using shRNA on the expressions of TrkA, TrkB, ShcB, cartilage differentiation-related factors and cell migration of IL-1β-stimulated normal chondrocytes. (a-g) The effects of shTrkA and shTrkB on the expressions of TrkA, TrkB, ShcB, and cartilage differentiation-related factors in IL-1β-stimulated chondrocytes were detected by qRT-PCR. GAPDH served as an internal reference. (h) The effects of shTrkA and shTrkB on migration of IL-1β-stimulated normal chondrocyte (CHON-001) were examined by a scratch assay. The magnification was 100 times. Normal chondrocytes: CHON-001. ** p < 0.01, *** p < 0.001 vs. Empty vector; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. IL-1β + empty vector