Skip to main content
. 2021 Nov 3;7(45):eabe3954. doi: 10.1126/sciadv.abe3954

Fig. 6. Deletion of Abi3 locus alters the levels of immune response proteins in 5XFAD mice.

Fig. 6.

Protein levels of chemokines and cytokines were measured in the PBS fraction of 8-month-old male 5XFAD mouse cortices using a 33-plex Bio-plex Pro mouse chemokine panel. (A) Among 33 proteins, 25 chemokines and cytokines were detected. Their differential protein levels are shown in the heatmap graph. (B to F) Significantly altered chemokines are shown as individual bar graphs. (B) CCL24, (C) CXCL10, (D) CCL3, and (E) CXCL16 were significantly increased, and (F) CCL25 was decreased in Abi3−/− mice compared to Abi3+/+ mice. All data were normalized by total protein level and given as means ± SEM. Unpaired t test; *P < 0.05 and **P < 0.01 (Abi3+/+, n = 5; Abi3−/−, n = 6). IFN-r, interferon receptor; IL, interleukin.