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. 2021 Nov 3;7(45):eabe3954. doi: 10.1126/sciadv.abe3954

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Fig. 9. — (A to F) Targeted scRNA-seq analysis identified 14 clusters of cells derived from 9-month-old male Abi3^+/+ and Abi3^−/− mouse brain (Abi3^+/+, n = 6970 cells; Abi3^−/−, n = 6799 cells). Each plot displays the raw counts on the y axis and cluster identity on the x axis. Among the DAM marker genes, the expression of (A) Apoe, (B) Cst7, (C) Itgax, and (D) Trem2 were analyzed for each cluster. (E) Cd8a, T cell marker gene, was detected only in cluster 7. (F) Iglc3, B cell marker gene, was detected only in cluster 14. (G) Heatmap showing DAM and homeostatic microglia marker genes across microglial clusters (0 to 6 and 10). The level of gene expression is averaged per gene across all clusters; up-regulation compared to the mean expression level is shown in yellow and down-regulation in blue.