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A and B, LPA (C18:1, 10 μm) constricts isolated, pressurized (60 mmHg) skeletal muscle arteries from wild-type but not TRPV1-null mice (n = 4, unpaired t test, ***P < 0.001). C and D, BP changes in wild-type (n = 4) and TRPV1-null (n = 6) mice in response to i.v. infusion (20 s)=of LPA (C18:1; unpaired t test, ***P < 0.001).
