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. Author manuscript; available in PMC: 2021 Nov 3.
Published in final edited form as: J Physiol. 2020 Oct 6;598(24):5639–5659. doi: 10.1113/JP279909

Figure 8. Capsaicin constricts coronary arterioles and reduces coronary perfusion.

Figure 8.

A and B, sagittal sections (150 μm) of hearts from TRPV1-Cre:tdTomato and TRPV1-nLacZ mice reveal TRPV1 expression in small arteriole branches (yellow arrowheads denote the left coronary artery). C–E, capsaicin preferentially constricts small arterioles in situ in slice preparations from the hearts of TRPV1-Cre:tdTomato mice. Data are normalized to KCl (40 mm) (n = 5, one-way ANOVA, *P < 0.05, **P < 0.01). F–H, capsaicin dose-dependently decreases coronary perfusion in isolated rat hearts (n = 7) without affecting the heart rate. BCTC (n = 3) abolishes the effect of capsaicin (one-way ANOVA, *P < 0.05, ***P < 0.001).