Table 3.

Studies included in the meta-analysis for the correlation between the serum AQP4-IgG titer and the Expanded Disability Status Scale (EDSS) score.

First author, year	No. of patients	Age	Ethnicity	AQP4-IgG test method	Diagnosis	Diagnostic criteria	Tx	n	r
Liang, 2019 (26)	97	42+	Chinese	CBA-IFI	NMOSD	2015a	na	65	0.30**
Li, 2013 (21)	16	41++	Chinese	CBA-IFI	NMO	2006b	None	9	0.90*
Isobe, 2012 (29)	29	49.3+	Japanese	CBA-FACS	NMO	1999c	None	18	0.31**

AQP4, aquaporin4; CBA, cell-based assay; EDSS, Expanded Disability Status Scale; FACS, fluorescence-activated cell sorting; IFI, indirect immunofluorescence; NMO, neuromyelitis optica; NMOSD, neuromyelitis optica spectrum disorder; n, number of samples; na, not available; r, correlation coefficient value; Tx, treatment.

⁺Indicates mean value;

⁺⁺Indicates median value.

^*Indicates Pearson correlation coefficient value.

^**Indicates Spearman correlation coefficient value.

^aWingerchuk et al., (5).

^bWingerchuk et al. (1).

^cWingerchuk et al. (3).