Table 1.
General characteristics of female and male Hannover Sprague-Dawley (HanSD) and transgenic rats (TGR) aged 9 months.
| Females | HanSD (n=8) | TGR (n=8) |
|---|---|---|
| Body weight (BW; g) | 353 ± 12 | 382 ± 8 |
| Heart weight (HW; mg) | 1165 ± 24 | 1253 ± 24 |
| Relative heart weight (HW/BW; mg/g | 3.33 ± 0.12 | 3.31 ± 0.13 |
| Kidney weight (KW; mg) | 2071 ± 46 | 2272 ± 46* |
| Relative kidney weight (KW/BW; mg/g) | 5.93 ± 0.29 | 5.97 ± 0.31 |
|
| ||
| Males | HanSD (n=6) | TGR (n=5) |
|
| ||
| Body weight (BW; g) | 690 ± 1# | 818 ± 24*# |
| Heart weight (HW; mg) | 1756 ± 21# | 2130 ± 55*# |
| Relative heart weight (HW/BW; mg/g | 2.55 ± 0.03# | 2.61 ± 0.09# |
| Left ventricular weight (LVW; mg) | 1376 ± 34 | 1720 ± 89* |
| Relative left ventricular weight (LVW/BW; mg/g) | 2.00 ± 0.02 | 2.12 ± 0.06 |
| Kidney weight (KW; mg) | 4289 ± 227# | 4762 ± 212# |
| Relative kidney weight (KW/BW; mg/g) | 6.22 ± 0.34 | 5.83 ± 0.26 |
| Liver weight (LW; mg) | 23757 ± 1921 | 28376 ± 2163* |
| Relative liver weight (LW/BW; mg/g) | 34.5 ± 2.9 | 34.7 ± 2.3 |
All values are mean ± SEM, n, number of animals is given in parentheses. Significantly different:
*
P ≤ 0.05 vs. HanSD,
#
P ≤ 0.05 vs. females.