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. Author manuscript; available in PMC: 2021 Nov 3.
Published in final edited form as: Int J Parasitol. 2020 Mar 26;50(5):413–422. doi: 10.1016/j.ijpara.2020.01.006

Fig. 2.

Fig. 2.

Substituents of chiral and non-chiral Bumped Kinase Inhibitors (BKIs). (A) BKI-1634’s R2 substituent contains a chiral oxolane ring. Modifying this to a six-membered oxane ring results in a loss of chirality. (B) BKIs-1712, -1713, -1768, and -1769 possess a chiral 4-hydroxybutan-2-yl R2 substituent. Addition of a methyl group to form the 4-hydroxy-2-methylbutan-2-yl substituent resolves chirality.