Figure 3.

Results of open field and novel object recognition tests. (a) Mice were placed in an open field chamber, and the patterns of movement were analyzed (n = 13 per group). IZ: inner zone. (b) Mice were placed in a chamber where a familiar and a novel object were each located at different corners. No. Entry to NO/FO (%): the number of entries to the novel object area compared to the entries to the familiar object area; discrimination index (%): the level of recognizing, remembering, and discriminating the novel object from the familiar object. (n = 18, 18, and 16 for sham, BCAO, and H2, respectively). NO: novel object; FO: familiar object; BCAO: bilateral common carotid artery occlusion. ^∗∗∗p < 0.0001, ^∗∗p < 0.01, and ^∗p < 0.05; n.s: not significant.