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. 2021 Oct 27;2021:9987376. doi: 10.1155/2021/9987376

Figure 3.

Figure 3

Related biological pathways and immune landscape characteristics of different m6A modification modes in breast cancer. GSVA enrichment analysis showed the biological pathways in three different m6A modification modes. Heat maps were used to visualize these biological processes. Red represents activated pathways, and blue represents inhibited pathways. (a) m6Acluster A vs. m6Acluster B; (b) m6Acluster A vs. m6Acluster C; (c) m6Acluster B vs. m6Acluster C; (d) CIBERSORT algorithm was used to evaluate the characteristics of immune infiltration between three m6A modification patterns. m6Acluster C showed a better interstitial score, immune score, and ESTIMATE score. (e) Abundance of immune-infiltrating cells in each tumor microenvironment in three different m6A modification patterns in breast cancer (∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001).