Table 1.
Completed clinical trials on mesenchymal stromal cell-based therapy during 2016-2020 (U. S. National Library of Medicine).
| Organ system | Disease/syndrome | Phase | Date | Country | Source | Transplantation | CT code |
|---|---|---|---|---|---|---|---|
| Cardiovascular | Cardiomyopathy | 1 | 2019 | United States | ND | Allotransplant | NCT02509156 |
| Cardiovascular | Graft versus host disease | 1 and 2 | 2016 | Pakistan | Bone marrow | Allotransplant | NCT02824653 |
| Cardiovascular | Ischemic cardiomyopathy | 2 | 2020 | United States | Bone marrow | Autotransplant | NCT02501811 |
| Gastrointestinal | Cirrhosis | 4 | 2020 | India | Bone marrow | Autotransplant | NCT04243681 |
| Gastrointestinal | Xerostomia | 2 | 2017 | Denmark | Adipose tissue | Autotransplant | NCT02513238 |
| Gastrointestinal | Type 2 diabetes mellitus | 1 and 2 | 2019 | Vietnam | Bone marrow | Autotransplant | NCT03343782 |
| Immune | Discordant immunological response in HIV | 1 and 2 | 2019 | Spain | Adipose tissue | Allotransplant | NCT02290041 |
| Immune | Systemic lupus erythematosus | 1 | 2018 | United States | Umbilical cord | Allotransplant | NCT03171194 |
| Integumentary | Atopic dermatitis | 1 | 2017 | Korea | ND | Autotransplant | NCT02888704 |
| Integumentary | Caesarean section scars | 2 | 2018 | China | Umbilical cord | Allotransplant | NCT02772289 |
| Integumentary | Chronic ulcer | 1 | 2020 | Indonesia | Conditioned medium Wharton's jelly |
Allotransplant | NCT04134676 |
| Integumentary | Chronic venous ulcer | 1 and 2 | 2020 | Germany | Skin | Allotransplant | NCT03257098 |
| Integumentary | Diabetic foot ulcer | 2 | 2016 | Korea | Adipose tissue | Allotransplant | NCT02619877 |
| Integumentary | Diabetic neuropathic ulcer | 1 and 2 | 2020 | Germany | Skin | Allotransplant | NCT03267784 |
| Integumentary | Gingival recession | 1 and 2 | 2019 | Belarus | Adipose tissue | Autotransplant | NCT04434794 |
| Integumentary | Perianal fistula | 1 | 2019 | United States | ND | Autotransplant | NCT02589119 |
| Integumentary | Recessive dystrophic epidermolysis bullosa | 1 and 2 | 2020 | Korea | Umbilical cord | Allotransplant | NCT04520022 |
| Integumentary | Rectovaginal fistula | 1 | 2019 | Russia | Adipose tissue | Autotransplant | NCT03643614 |
| Integumentary | Skin scar | 1 and 2 | 2019 | Poland | Adipose tissue | Autotransplant | NCT03887208 |
| Integumentary | Skin wound | 1 | 2019 | Pakistan | Umbilical cord | Allotransplant | NCT04219657 |
| Integumentary | Surgical leak fistula | 1 | 2019 | United States | Adipose tissue | Autotransplant | NCT02807389 |
| Integumentary | Ultrafiltration failure | 1 and 2 | 2017 | Iran | Adipose tissue | Allotransplant | NCT02801890 |
| Nervous | Alzheimer's disease | 1 and2 | 2019 | United States | Adipose tissue | Autotransplant | NCT03117738 |
| Nervous | Brain death | 1 | 2020 | India | ND | ND | NCT02742857 |
| Nervous | Cerebral infarction | 1 and 2 | 2017 | Korea | Umbilical cord | Allotransplant | NCT02378974 |
| Nervous | Corneal ulcer Corneal disease Corneal dystrophy |
1&2 | 2019 | Belarus | Adipose tissue | Autotransplant | NCT04484402 |
| Nervous | Motor neuron disease | 1 | 2016 | Brazil | ND | Autotransplant | NCT02987413 |
| Nervous | Multiple sclerosis | 2 | 2019 | Canada | ND | Autotransplant | NCT02239393 |
| Nervous | Multiple sclerosis | 1 and 2 | 2020 | Jordan | Umbilical cord | Allotransplant | NCT03326505 |
| Nervous | Multiple sclerosis | 2 | 2018 | Israel | Bone marrow | Autotransplant | NCT02166021 |
| Nervous | Multiple sclerosis | 1 and2 | 2017 | Spain | Bone marrow | Autotransplant | NCT02495766 |
| Nervous | Ocular corneal burn | 2 | 2017 | China | Bone marrow | ND | NCT02325843 |
| Nervous | Parkinson's disease | 1 | 2019 | United States | Bone marrow | Autotransplant | NCT02611167 |
| Nervous | Refractory epilepsy | 1 | 2019 | Russia | Adipose tissue | Autotransplant | NCT03676569 |
| Nervous | Retinitis pigmentosa | 3 | 2019 | Turkey | Wharton's jelly | Allotransplant | NCT04224207 |
| Nervous | Spinal cord injuries | 1 and 2 | 2018 | Jordan | Bone marrow Adipose tissue |
Autotransplant | NCT02981576 |
| Nervous | Spinal cord injuries | 1 and 2 | 2020 | China | Umbilical cord | Allotransplant | NCT02481440 |
| Nervous | Spinal cord injuries | 2 | 2017 | Spain | Bone marrow | Autotransplant | NCT02570932 |
| Nervous | Spinal cord injury | 1 and 2 | 2019 | Spain | Wharton's jelly | Allotransplant | NCT03003364 |
| Reproductive | Atrophic endometrium | 2 | 2019 | Russia | Bone marrow | Autotransplant | NCT03166189 |
| Reproductive | Erectile dysfunction | 1 | 2018 | Korea | Bone marrow | Autotransplant | NCT02344849 |
| Reproductive | Erectile dysfunction | 1 | 2018 | Jordan | Wharton's jelly | Allotransplant | NCT02945449 |
| Reproductive | Erectile dysfunction | 1 and 2 | 2019 | Jordan | Wharton's jelly | Allotransplant | NCT03751735 |
| Reproductive | Fistula vagina | 1 | 2020 | United States | ND | Autotransplant | NCT03220243 |
| Reproductive | Ovarian cancer | 1 | 2019 | United States | ND | Autotransplant | NCT02530047 |
| Reproductive | Premature ovarian failure | 1 and 2 | 2018 | China | Umbilical cord | Allotransplant | NCT02644447 |
| Respiratory | Acute respiratory distress syndrome | 1 | 2019 | United States | Bone marrow | Allotransplant | NCT02804945 |
| Respiratory | Bronchopulmonary dysplasia | 1 and 2 | 2016 | United States | Umbilical cord | Allotransplant | NCT02381366 |
| Respiratory | COVID-19 Acute respiratory distress syndrome |
1 and 2 | 2020 | United States | Umbilical cord | Allotransplant | NCT04355728 |
| Respiratory | COVID-19 Prophylaxis |
1 | 2020 | United States | Umbilical cord | Allotransplant | NCT04573270 |
| Respiratory | COVID-19 | 2 | 2020 | China | Umbilical cord | Allotransplant | NCT04288102 |
| Respiratory | COVID-19 | 1 | 2020 | China | Exosome Adipose tissue |
Allotransplant | NCT04276987 |
| Respiratory | Laryngotracheal stenosis | 1 and 2 | 2019 | Belarus | Olfactory mucosa | Autotransplant | NCT03130374 |
| Respiratory | Noncystic fibrosis bronchiectasis | 1 | 2019 | United States | Bone marrow | Allotransplant | NCT02625246 |
| Respiratory | Pneumoconiosis | 1 | 2019 | China | Umbilical cord | Allotransplant | NCT02668068 |
| Skeletal | Bone fracture | 1 and 2 | 2020 | India | Adipose tissue | Autotransplant | NCT04340284 |
| Skeletal | Dental implant therapy | 1 and 2 | 2017 | Greece | Bone marrow | Autotransplant | NCT03070275 |
| Skeletal | Knee osteoarthritis | 2 | 2018 | United States | Bone marrow | Autotransplant | NCT02958267 |
| Skeletal | Knee osteoarthritis | 1 and 2 | 2018 | Canada | Bone marrow | Autotransplant | NCT02351011 |
| Skeletal | Knee osteoarthritis | 2 | 2018 | United States | Adipose tissue | Autotransplant | NCT02674399 |
| Skeletal | Osteoarthritis | 1 | 2018 | China | Adipose tissue | Allotransplant | NCT02641860 |
| Skeletal | Osteonecrosis | 1 and 2 | 2018 | Spain | Bone marrow | Autotransplant | NCT01605383 |
| Skeletal | Osteoporosis Spinal fractures |
1 | 2016 | Spain | Bone marrow | Autotransplant | NCT02566655 |
| Skeletal | Rheumatoid arthritis | 1 | 2018 | Iran | Bone marrow | Autotransplant | NCT03333681 |
| Skeletal | Rheumatoid arthritis | 1 and 2 | 2020 | United States | Adipose tissue | Autotransplant | NCT03691909 |
| Urinary | Stress urinary incontinence | 1 and 2 | 2019 | Belarus | Adipose tissue | Autotransplant | NCT04446884 |
| Urinary | Stress urinary incontinence | 3 | 2016 | Egypt | Bone marrow | Autotransplant | NCT02334878 |
ND: no data.