Table 3.
Recruiting clinical trials on mesenchymal stromal/stem cell-based therapy started during 2016-2020 (U. S. National Library of Medicine).
| Organ system | Disease/syndrome | Phase | Date | Country | Source | Transplantation | CT code |
|---|---|---|---|---|---|---|---|
| Cardiovascular | Abdominal aortic aneurysm | 1 | 2016 | United States | ND | Allotransplant | NCT02846883 |
| Cardiovascular | Acute myocardial infarction | 1 and 2 | 2019 | Indonesia | Umbilical cord | Allotransplant | NCT04340609 |
| Cardiovascular | Acute myocardial infarction | 1 | 2019 | Taiwan | Umbilical cord | Allotransplant | NCT04056819 |
| Cardiovascular | Cardiomyopathy | 1 | 2020 | United States | Bone marrow | Allotransplant | NCT02962661 |
| Cardiovascular | Cerebrovascular disorders | 1 and 2 | 2019 | Iran | Exosome | Allotransplant | NCT03384433 |
| Cardiovascular | Critical limb ischemia | 1 | 2020 | Korea | Adipose tissue | Allotransplant | NCT04661644 |
| Cardiovascular | Critical limb ischemia | 2 | 2020 | France | Adipose tissue | Autotransplant | NCT03968198 |
| Cardiovascular | Diabetic foot ulcer | 3 | 2020 | Korea | Adipose tissue | Allotransplant | NCT04569409 |
| Cardiovascular | Diabetic foot ulcer | 1 | 2020 | China | Umbilical cord | Allotransplant | NCT04464213 |
| Cardiovascular | Heart defects | 1 and 2 | 2017 | United States | ND | Allotransplant | NCT03079401 |
| Cardiovascular | Heart failure | 1 | 2016 | United States | Bone marrow | Allotransplant | NCT02408432 |
| Cardiovascular | Heart failure | 2 and 3 | 2018 | Poland | Wharton's jelly | Allotransplant | NCT03418233 |
| Cardiovascular | Ischemia | 1 | 2017 | United States | Bone marrow | Allotransplant | NCT02685098 |
| Cardiovascular | Ischemia reperfusion injury | 2 | 2020 | United States | Adipose tissue | Allotransplant | NCT04388761 |
| Cardiovascular | Ischemic heart disease | 1 and 2 | 2018 | China | Bone marrow | Autotransplant | NCT03397095 |
| Cardiovascular | Ischemic stroke | 1 | 2020 | Taiwan | Umbilical cord | Allotransplant | NCT04434768 |
| Cardiovascular | Ischemic stroke | 1 | 2019 | Taiwan | Umbilical cord | Allotransplant | NCT04097652 |
| Cardiovascular | Myocardial infarction | 1 | 2019 | Spain | Umbilical cord | Allotransplant | NCT03798353 |
| Cardiovascular | Myocardial infarction | 2 and 3 | 2017 | Poland | Wharton's jelly | Allotransplant | NCT03404063 |
| Cardiovascular | Myocardial ischemia | 2 | 2016 | France | Bone marrow | Autotransplant | NCT02462330 |
| Digestive | Crohn colitis | 1 and 2 | 2020 | United States | Bone marrow | Allotransplant | NCT04548583 |
| Digestive | Crohn disease | 1 | 2018 | United States | ND | Autotransplant | NCT03449069 |
| Digestive | Crohn disease | 1 and 2 | 2018 | Belgium | ND | ND | NCT03901235 |
| Digestive | Fistula | 1 and 2 | 2020 | United States | Bone marrow | Allotransplant | NCT04519671 |
| Digestive | Fistula | 1 and 2 | 2020 | United States | Bone marrow | Allotransplant | NCT04519684 |
| Digestive | Hepatitis B | 1 | 2018 | China | Umbilical cord | Allotransplant | NCT03826433 |
| Digestive | Liver cirrhosis | 1 and 2 | 2018 | Singapore | Bone marrow | Autotransplant | NCT03626090 |
| Digestive | Liver cirrhosis | 2 | 2019 | China | Umbilical cord | Allotransplant | NCT03945487 |
| Digestive | Liver cirrhosis | 1 and 2 | 2018 | Indonesia | Umbilical cord | Allotransplant | NCT04357600 |
| Digestive | Liver failure | 1 and 2 | 2019 | Germany | Skin | Allotransplant | NCT03860155 |
| Digestive | Liver transplantation | 1 | 2017 | Germany | Bone marrow | Allotransplant | NCT02957552 |
| Digestive | Primary biliary cirrhosis | 1 and 2 | 2019 | Vietnam | Umbilical cord | Allotransplant | NCT04522869 |
| Digestive | Rectovaginal fistula | 1 and 2 | 2020 | United States | Bone marrow | Allotransplant | NCT04519697 |
| Digestive | Ulcerative colitis | 1 and 2 | 2018 | China | Adipose tissue | Allotransplant | NCT03609905 |
| Digestive | Ulcerative colitis | 1 | 2020 | United States | Adipose tissue | Autotransplant | NCT04312113 |
| Digestive | Ulcerative colitis | 1 and 2 | 2020 | United States | Bone marrow | Allotransplant | NCT04543994 |
| Endocrine | Diabetic kidney disease | 1 | 2019 | United States | Adipose tissue | Autotransplant | NCT03840343 |
| Endocrine | Type 1 diabetes | 1 | 2017 | Jordan | Adipose tissue | Allotransplant | NCT02940418 |
| Endocrine | Type 1 diabetes | 1 and 2 | 2019 | Sweden | Wharton's jelly | Allotransplant | NCT03973827 |
| Endocrine | Type 2 diabetes | 1 and 2 | 2016 | Indonesia | Bone marrow Umbilical cord |
Autotransplant Allotransplant |
NCT04501341 |
| Endocrine | Type 2 diabetes | 1 and 2 | 2020 | China | Umbilical cord | Allotransplant | NCT04441658 |
| Immune | Acute graft versus host disease | 1 and 2 | 2019 | Malaysia | Umbilical cord | Allotransplant | NCT03847844 |
| Immune | Diabetic foot ulcer | 1 | 2019 | United States | Umbilical cord | Allotransplant | NCT04104451 |
| Immune | Drug resistant | 1 and 2 | 2020 | China | Adipose tissue | Allotransplant | NCT04544215 |
| Immune | Keratoconjunctivitis sicca | 2 | 2020 | Denmark | Adipose tissue | Allotransplant | NCT04615455 |
| Immune | Lupus erythematosus | 1 and 2 | 2019 | Belarus | Olfactory mucosa | Allotransplant | NCT04184258 |
| Immune | Lymphoblastic leukemia | 2 | 2017 | United States | Umbilical cord | Autotransplant | NCT03096782 |
| Immune | Primary sclerosing cholangitis Autoimmune hepatitis |
1 and 2 | 2018 | United Kingdom | Umbilical cord | Allotransplant | NCT02997878 |
| Immune | Renal lupus | 2 | 2019 | Chile | Umbilical cord | Allotransplant | NCT03917797 |
| Immune | Type 1 diabetes | 1 | 2020 | United States | Umbilical cord | Allotransplant | NCT04061746 |
| Immune | Type 1 diabetes | 1 and 2 | 2017 | Sweden | Wharton's jelly | Allotransplant | NCT03406585 |
| Integumentary | Caesarean section scars | 2 | 2020 | China | Perinatal tissue | Allotransplant | NCT04034615 |
| Integumentary | Psoriasis | 1 and 2 | 2019 | China | Adipose tissue | Allotransplant | NCT03392311 |
| Integumentary | Wound | 1 | 2019 | China | ND Conditioned medium |
ND | NCT04235296 |
| Nervous | Alzheimer's disease | 1 and 2 | 2020 | China | Adipose tissue | Allotransplant | NCT04388982 |
| Nervous | Alzheimer's disease | 1 | 2019 | United States | Umbilical cord | Allotransplant | NCT04040348 |
| Nervous | Amyotrophic lateral sclerosis | 2 | 2017 | United States | Adipose tissue | Autotransplant | NCT03268603 |
| Nervous | Amyotrophic lateral sclerosis | 1 and 2 | 2020 | Poland | Wharton's jelly | Allotransplant | NCT04651855 |
| Nervous | Cerebral palsy | 1 and 2 | 2020 | Indonesia | Umbilical cord | Allotransplant | NCT04314687 |
| Nervous | Cornea | 1 | 2020 | United States | Bone marrow | Allotransplant | NCT04626583 |
| Nervous | Dry eye | 1 and 2 | 2020 | China | Umbilical cord Exosome |
Allotransplant | NCT04213248 |
| Nervous | Nonarteritic anterior ischemic optic neuropathy | 2 | 2018 | Spain | Bone marrow | Allotransplant | NCT03173638 |
| Nervous | Parkinson's disease | 1 and 2 | 2018 | Jordan | Umbilical cord | Allotransplant | NCT03684122 |
| Nervous | Parkinson's disease | 2 | 2020 | United States | Bone marrow | Allotransplant | NCT04506073 |
| Nervous | Recurrent glioblastoma | 1 | 2019 | United States | Bone marrow | Allotransplant | NCT03896568 |
| Nervous | Sclerosis | 1 | 2016 | Jordan | Bone marrow | Autotransplant | NCT03069170 |
| Nervous | Spinal cord injuries | 1 and 2 | 2016 | Spain | Adipose tissue | Allotransplant | NCT02917291 |
| Nervous | Spinal cord injuries | 2 | 2020 | United States | Adipose tissue | Autotransplant | NCT04520373 |
| Nervous | Spinal cord injuries | 1 | 2017 | Jordan | Bone marrow | Autotransplant | NCT04288934 |
| Nervous | Spinal cord injuries | 2 | 2019 | China | Umbilical cord | Allotransplant | NCT03521336 |
| Nervous | Spinal cord injuries | 2 | 2019 | China | Umbilical cord | Allotransplant | NCT03521323 |
| Nervous | Spinal cord injuries | 2 | 2019 | China | Umbilical cord | Allotransplant | NCT03505034 |
| Nervous | Stroke | 1 and 2 | 2020 | Netherlands | Bone marrow | Allotransplant | NCT03356821 |
| Nervous | Traumatic brain injury | 1 and 2 | 2020 | United States | Adipose tissue | Autotransplant | NCT04063215 |
| Reproductive | Erectile dysfunction | 2 | 2020 | Korea | Bone marrow | Autotransplant | NCT04594850 |
| Reproductive | Intraventricular hemorrhage | 2 | 2017 | Korea | Umbilical cord | Allotransplant | NCT02890953 |
| Reproductive | Uterine scar | 1 | 2020 | China | Umbilical cord | Allotransplant | NCT03181087 |
| Reproductive | Uterine scar | 2 | 2020 | China | Umbilical cord | Allotransplant | NCT02968459 |
| Reproductive | Uterus injury | 2 | 2020 | China | Umbilical cord | Allotransplant | NCT03386708 |
| Respiratory | Acute respiratory distress syndrome | 1 and 2 | 2019 | Spain | Adipose tissue | Allotransplant | NCT04289194 |
| Respiratory | Acute respiratory distress syndrome | 2 | 2019 | United States | Bone marrow | Allotransplant | NCT03818854 |
| Respiratory | Acute respiratory distress syndrome | 1 and 2 | 2020 | United States | ND | Allotransplant | NCT04524962 |
| Respiratory | Acute respiratory distress syndrome | 1 and 2 | 2019 | United Kingdom | Umbilical cord | Allotransplant | NCT03042143 |
| Respiratory | Adenocarcinoma of lung | 1 and 2 | 2019 | United Kingdom | ND | Allotransplant | NCT03298763 |
| Respiratory | Bronchopulmonary dysplasia | 1 | 2019 | United States | Bone marrow Exosome |
Allotransplant | NCT03857841 |
| Respiratory | Bronchopulmonary dysplasia | 1 | 2019 | Spain | ND | ND | NCT02443961 |
| Respiratory | Bronchopulmonary dysplasia | 1 and 2 | 2019 | China | Umbilical cord | Allotransplant | NCT03645525 |
| Respiratory | Bronchopulmonary dysplasia | 1 | 2018 | China | Umbilical cord | Allotransplant | NCT03873506 |
| Respiratory | Bronchopulmonary dysplasia | 1 and 2 | 2019 | China | Umbilical cord | Allotransplant | NCT03774537 |
| Respiratory | Bronchopulmonary dysplasia | 1 | 2018 | China | Umbilical cord | Allotransplant | NCT03558334 |
| Respiratory | Bronchopulmonary dysplasia | 2 | 2018 | Korea | Umbilical cord | Allotransplant | NCT03392467 |
| Respiratory | Bronchopulmonary dysplasia | 2 | 2019 | Korea | Umbilical cord | Allotransplant | NCT04003857 |
| Respiratory | Bronchopulmonary dysplasia | 1 | 2018 | Taiwan | Umbilical cord | Allotransplant | NCT03631420 |
| Respiratory | Bronchopulmonary dysplasia | 1 | 2019 | Vietnam | Umbilical cord | Allotransplant | NCT04062136 |
| Respiratory | Chronic lung allograft dysfunction | 2 | 2017 | Australia | Bone marrow | Allotransplant | NCT02709343 |
| Respiratory | Chronic obstructive pulmonary disease | 1 | 2020 | United States | ND | ND | NCT04047810 |
| Respiratory | Chronic obstructive pulmonary disease | 1 and 2 | 2020 | Vietnam | Umbilical cord | Allotransplant | NCT04433104 |
| Respiratory | Chronic obstructive pulmonary disease | 1 | 2020 | Taiwan | Umbilical cord | Allotransplant | NCT04206007 |
| Respiratory | COVID-19 | 1 | 2020 | Mexico | Adipose tissue | Allotransplant | NCT04611256 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | Belgium | Bone marrow | Allotransplant | NCT04445454 |
| Respiratory | COVID-19 | 1 | 2020 | Canada | Bone marrow | Allotransplant | NCT04400032 |
| Respiratory | COVID-19 | 2 | 2020 | Pakistan | Bone marrow | Allotransplant | NCT04444271 |
| Respiratory | COVID-19 | 2 | 2020 | Spain | Bone marrow | Allotransplant | NCT04361942 |
| Respiratory | COVID-19 | 1 | 2020 | Sweden | Bone marrow | Allotransplant | NCT04447833 |
| Respiratory | COVID-19 | 1 | 2020 | United States | Bone marrow | Allotransplant | NCT04397796 |
| Respiratory | COVID-19 | 3 | 2020 | United States | Bone marrow | Allotransplant | NCT04371393 |
| Respiratory | COVID-19 | 1 | 2020 | United States | Bone marrow | Allotransplant | NCT04629105 |
| Respiratory | COVID-19 | 1 | 2020 | United States | Cord blood | Allotransplant | NCT04565665 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | United States | Wharton's jelly | Allotransplant | NCT04399889 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | China | Dental pulp | Allotransplant | NCT04336254 |
| Respiratory | COVID-19 | 1 | 2020 | Indonesia | ND | Allotransplant | NCT04535856 |
| Respiratory | COVID-19 | 2 | 2020 | Mexico | ND | Allotransplant | NCT04416139 |
| Respiratory | COVID-19 | 2 | 2020 | Spain | ND | Allotransplant | NCT04615429 |
| Respiratory | COVID-19 | 2 | 2020 | United States | ND | Allotransplant | NCT04466098 |
| Respiratory | COVID-19 | 1 | 2020 | Brazil | ND | Allotransplant | NCT04525378 |
| Respiratory | COVID-19 | 2 and 3 | 2020 | Iran | ND Exosome |
ND | NCT04366063 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | United States | ND | Allotransplant | NCT04524962 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | Ukraine | Umbilical cord | Allotransplant | NCT04461925 |
| Respiratory | COVID-19 | 2 | 2020 | Germany Israel |
Umbilical cord | Allotransplant | NCT04614025 |
| Respiratory | COVID-19 | 2 | 2020 | United States | Umbilical cord | Allotransplant | NCT04389450 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | China | Umbilical cord | Allotransplant | NCT04339660 |
| Respiratory | COVID-19 | 1 | 2020 | Indonesia | Umbilical cord | Allotransplant | NCT04457609 |
| Respiratory | COVID-19 | 2 | 2020 | Spain | Umbilical cord | Allotransplant | NCT04366271 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | United States | Umbilical cord | Allotransplant | NCT04494386 |
| Respiratory | COVID-19 | 2 | 2020 | Pakistan | Umbilical cord | Allotransplant | NCT04437823 |
| Respiratory | COVID-19 | 1 | 2020 | China | Umbilical cord | Allotransplant | NCT04252118 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | Turkey | Umbilical cord | Allotransplant | NCT04392778 |
| Respiratory | COVID-19 | 1 | 2020 | Jordan | Wharton's jelly | Allotransplant | NCT04313322 |
| Respiratory | COVID-19 | 1 and 2 | 2020 | Spain | Wharton's jelly | Allotransplant | NCT04390139 |
| Respiratory | Healthy | 1 | 2020 | China | Adipose tissue exosome | Allotransplant | NCT04313647 |
| Respiratory | Hoarseness | 1 and 2 | 2020 | Sweden | Bone marrow | Autotransplant | NCT04290182 |
| Respiratory | Lung disease | 1 | 2019 | United States | Bone marrow | Allotransplant | NCT03929120 |
| Respiratory | Pneumonia | 2 | 2020 | China | Umbilical cord | Allotransplant | NCT04269525 |
| Respiratory | Pulmonary hypertension | 1 and 2 | 2019 | China | Adipose tissue | Autotransplant | NCT04055415 |
| Skeletal | Alveolar bone atrophy | 3 | 2020 | Spain | Bone marrow | Autotransplant | NCT04297813 |
| Skeletal | Aneurysmal bone cyst | 1 and 2 | 2018 | Jordan | Bone marrow | Autotransplant | NCT03066245 |
| Skeletal | Cartilage defect | 1 | 2018 | United States | Adipose tissue | Autotransplant Allotransplant |
NCT03672825 |
| Skeletal | Disc disease | 2 | 2017 | Indonesia | Bone marrow | Allotransplant | NCT04499105 |
| Skeletal | Disc disease | 1 | 2019 | China | Umbilical cord | Allotransplant | NCT04104412 |
| Skeletal | Knee cartilage injury | 1 and 2 | 2018 | China | Adipose tissue | Autotransplant | NCT03955497 |
| Skeletal | Knee osteoarthritis | 2 | 2020 | China | Adipose tissue | Allotransplant | NCT04208646 |
| Skeletal | Knee osteoarthritis | 1 and 2 | 2019 | Taiwan | Adipose tissue | Allotransplant | NCT03943576 |
| Skeletal | Knee osteoarthritis | 1 and 2 | 2019 | Poland | Adipose tissue | Autotransplant | NCT03869229 |
| Skeletal | Knee osteoarthritis | 1 | 2017 | Jordan | Adipose tissue | Autotransplant | NCT02966951 |
| Skeletal | Knee osteoarthritis | 1 and 2 | 2020 | Ukraine | Bone marrow | Allotransplant | NCT04453111 |
| Skeletal | Knee osteoarthritis | 1 and 2 | 2019 | Korea | Bone marrow | Allotransplant | NCT04240873 |
| Skeletal | Knee osteoarthritis | 1 | 2018 | United States | Bone marrow | Autotransplant | NCT03477942 |
| Skeletal | Knee osteoarthritis | 1 | 2019 | Chile | Umbilical cord | Allotransplant | NCT03810521 |
| Skeletal | Knee osteoarthritis | 1 | 2019 | Korea | Umbilical cord | Allotransplant | NCT04037345 |
| Skeletal | Knee osteoarthritis | 1 | 2020 | Korea | Umbilical cord | Allotransplant | NCT04339504 |
| Skeletal | Knee osteoarthritis | 1 | 2017 | Jordan | Wharton's jelly | Allotransplant | NCT02963727 |
| Skeletal | Low back pain | 1 | 2020 | United States | Bone marrow | Allotransplant | NCT04410731 |
| Skeletal | Meniscus injuries | 2 | 2019 | United States | Adipose tissue | Autotransplant | NCT04274543 |
| Skeletal | Nonunion fracture | 3 | 2017 | France Germany |
Bone marrow | Autotransplant | NCT03325504 |
| Skeletal | Osteoarthritis | 2 | 2016 | France | Adipose tissue | Autotransplant | NCT02838069 |
| Skeletal | Osteoarthritis | 1 | 2016 | United States | Adipose tissue | Autotransplant | NCT02805855 |
| Skeletal | Osteoarthritis | 1 | 2018 | United States | Adipose tissue | Autotransplant | NCT03608579 |
| Skeletal | Osteoarthritis | 3 | 2019 | United States | Bone marrow Adipose tissue |
Autotransplant | NCT03818737 |
| Skeletal | Osteoarthritis | 2 | 2020 | China | Umbilical cord | Allotransplant | NCT03383081 |
| Skeletal | Osteoarthritis | 1 and 2 | 2020 | Indonesia | Umbilical cord | Allotransplant | NCT04314661 |
| Skeletal | Osteoarthritis | 1 and 2 | 2019 | Poland | Wharton's jelly | Allotransplant | NCT03866330 |
| Skeletal | Osteochondral fracture of talus | 3 | 2019 | Chile | Umbilical cord | Allotransplant | NCT03905824 |
| Skeletal | Osteogenesis imperfecta | 1 and 2 | 2019 | Sweden | Fetal liver | Allotransplant | NCT03706482 |
| Skeletal | Osteoporosis | 2 | 2020 | Indonesia | Umbilical cord | Allotransplant | NCT04501354 |
| Skeletal | Rheumatoid arthritis | 1 | 2017 | United States | ND | Allotransplant | NCT03186417 |
| Skeletal | Rheumatoid arthritis | 1 and 2 | 2018 | Korea | Umbilical cord | Allotransplant | NCT03618784 |
| Skeletal | Rotator cuff tear | 2 | 2020 | Brazil | ND | ND | NCT03362424 |
| Skeletal | Spinal tuberculosis | 2 | 2017 | Indonesia | ND | ND | NCT04493918 |
| Urinary | COVID-19 | 1 and 2 | 2020 | United States | Bone marrow | Allotransplant | NCT04445220 |
| Urinary | Kidney diseases | 1 and 2 | 2019 | Bangladesh | Adipose tissue | Autotransplant | NCT03939741 |
| Urinary | Kidney diseases | 1 and 2 | 2017 | Ireland Italy United Kingdom |
Bone marrow | Allotransplant | NCT02585622 |
| Urinary | Nephropathy | 1 | 2020 | Japan | Adipose tissue | Allotransplant | NCT04342325 |
| Urinary | Pelvic radiation | 2 | 2019 | France | ND | ND | NCT02814864 |
| Urinary | Renal | 1 | 2020 | United States | Adipose tissue | Allotransplant | NCT04392206 |
| Urinary | Renal transplantation | 1 | 2018 | United States | ND | Allotransplant | NCT03504241 |
| Urinary | Renal transplantation | 2 | 2016 | United States | ND | Autotransplant | NCT03478215 |
| Urinary | Type 2 diabetes | 1 and 2 | 2020 | China | Umbilical cord | Allotransplant | NCT04216849 |
ND: no data.