Table 4.
Diseases can be tested clinically for treatment with mesenchymal stromal/stem cells in human based on the successful in vivo model studies.
| Organ system | Disease/syndrome | Source | Transplantation | References |
|---|---|---|---|---|
| Cardiovascular | Myelodysplastic syndromes | Bone marrow | Allotransplant | [114] |
| Gastrointestinal | Hepatic failure | Bone marrow | Allotransplant | [115] |
| Nervous | Epilepticus | Exosome | Allotransplant | [117] |
| Nervous | Glioblastoma | Bone marrow | Allotransplant | [118] |
| Nervous | Glioblastoma | Adipose tissue | Allotransplant | [119] |
| Nervous | Hypoxic-ischemic encephalopathy | Umbilical cord | Allotransplant | [120] |
| Nervous | Loss of retinal ganglion cells | Bone marrow-derived exosomes | Allotransplant | [121] |
| Nervous | Nerve regeneration | Bone marrow | Allotransplant | [122] |
| Reproductive | Azoospermia | Adipose tissue | Allotransplant | [123] |
| Reproductive | Azoospermia | Bone marrow | Allotransplant | [124] |
| Reproductive | Mammary adenocarcinoma | Adipose tissue | Allotransplant | [116] |
| Skeletal | Bone formation | ND | Allotransplant | [125] |
| Skeletal | Calvarial defects | Bone marrow Adipose tissue |
Allotransplant | [126] |
| Skeletal | Periodontal defects | Exosome | Allotransplant | [127] |
| Urinary | Focal segmental glomerulosclerosis | Bone marrow | Allotransplant | [128] |
| Urinary | Nephron generation in kidney cortices | ND | Allotransplant | [129] |
ND: no data.