Table 4.

Antiviral properties of the synthesized conjugates and standard references (hydroxychloroquine and chloroquine) against SARS-CoV-2.

Entry	Compd.	IC50 (µM)a	CC50 (µM)b	SIc
1	5a	4.729	87.62	18.5
2	5b	3.406	77.44	22.7
3	5c	28.37	49.54	1.7
4	5d	1.659	90.82	54.7
5	5e	1.765	66.03	37.4
6	5f	149.3	182.1	1.2
7	5 g	4.079	234.5	57.5
8	5 h	2.236	78.19	35.0
9	5i	3.316	416.5	125.6
10	5j	32.29	182.6	5.7
11	5 k	5.868	60.60	10.3
12	5 l	5.898	65.19	11.1
13	5 m	4.173	578.6	138.7
14	5n	6.596	586.2	88.9
15	5o	1.690	57.50	34.0
16	5p	8.828	2062	233.6
17	Hydroxychloroquine	36.92	356.4	9.7
18	Chloroquine	24.98	377.7	15.1

^aIC₅₀ is the concentration for 50% growth inhibition relative to the control. ^bCC₅₀ is the cytotoxic concentration for 50% cell (VERO-E6) relative to the control. ^cSI =$\frac{{\mathit{CC}}_{50}}{{\mathit{IC}}_{50}}$