Table 2.
Risk of All-Cause Mortality, Myocardial Infarction, and Stroke by Impaired Fasting Glucose Exposure Score in Subgroups According to Age, Sex, Obesity, and Smoking
| IFG exposure score | P for interaction | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| 0 | 1 | 2 | 3 | 4 | ||
| Mortality | ||||||
| Age, yr | ||||||
| <65 | 1 (reference) | 1.11 (1.08–1.15) | 1.19 (1.14–1.24) | 1.20 (1.14–1.27) | 1.18 (1.10–1.28) | 0.053 |
| ≥65 | 1 (reference) | 1.13 (1.04–1.24) | 1.04 (0.93–1.16) | 1.25 (1.10–1.42) | 1.23 (1.03–1.46) | |
| Sex | ||||||
| Men | 1 (reference) | 1.12 (1.08–1.16) | 1.18 (1.13–1.23) | 1.20 (1.13–1.26) | 1.18 (1.10–1.27) | 0.052 |
| Women | 1 (reference) | 1.10 (1.01–1.20) | 1.01 (0.89–1.16) | 1.30 (1.10–1.53) | 1.24 (0.95–1.60) | |
| Obesity, kg/m2 | ||||||
| <25 | 1 (reference) | 1.12 (1.08–1.16) | 1.20 (1.14–1.26) | 1.19 (1.12–1.27) | 1.19 (1.09–1.29) | 0.016 |
| ≥25 | 1 (reference) | 1.08 (1.02–1.14) | 1.05 (0.98–1.13) | 1.17 (1.07–1.28) | 1.12 (1.00–1.26) | |
| Smoking | ||||||
| No | 1 (reference) | 1.09 (1.04–1.14) | 1.09 (1.04–1.15) | 1.17 (1.10–1.24) | 1.20 (1.10–1.30) | 0.022 |
| Current | 1 (reference) | 1.14 (1.09–1.19) | 1.23 (1.17–1.30) | 1.26 (1.18–1.35) | 1.18 (1.07–1.30) | |
|
| ||||||
| MI | ||||||
| Age, yr | ||||||
| <65 | 1 (reference) | 1.08 (1.03–1.13) | 1.14 (1.07–1.21) | 1.10 (1.02–1.19) | 1.15 (1.04–1.27) | 0.071 |
| ≥65 | 1 (reference) | 1.36 (1.14–1.62) | 1.19 (0.96–1.48) | 1.16 (0.89–1.52) | 1.12 (0.78–1.62) | |
| Sex | ||||||
| Men | 1 (reference) | 1.08 (1.03–1.14) | 1.12 (1.06–1.19) | 1.11 (1.03–1.20) | 1.15 (1.04–1.27) | 0.306 |
| Women | 1 (reference) | 1.19 (1.06–1.33) | 1.30 (1.11–1.51) | 1.08 (0.86–1.36) | 1.06 (0.75–1.51) | |
| Obesity, kg/m2 | ||||||
| <25 | 1 (reference) | 1.10 (1.04–1.16) | 1.16 (1.08–1.25) | 1.07 (1.00–1.18) | 1.15 (1.01–1.31) | 0.448 |
| ≥25 | 1 (reference) | 1.10 (1.03–1.19) | 1.14 (1.04–1.25) | 1.18 (1.06–1.32) | 1.18 (1.02–1.37) | |
| Smoking | ||||||
| No | 1 (reference) | 1.11 (1.05–1.18) | 1.14 (1.06–1.22) | 1.10 (1.01–1.21) | 1.13 (1.01–1.27) | 0.922 |
| Current | 1 (reference) | 1.08 (1.01–1.15) | 1.12 (1.04–1.21) | 1.13 (1.03–1.25) | 1.15 (1.01–1.32) | |
|
| ||||||
| Stroke | ||||||
| Age, yr | ||||||
| <65 | 1 (reference) | 1.08 (1.03–1.13) | 1.10 (1.03–1.16) | 1.10 (1.02–1.18) | 1.03 (0.93–1.14) | 0.209 |
| ≥65 | 1 (reference) | 1.09 (0.96–1.25) | 1.08 (0.92–1.26) | 0.97 (0.79–1.19) | 1.27 (0.99–1.64) | |
| Sex | ||||||
| Men | 1 (reference) | 1.09 (1.04–1.14) | 1.09 (1.03–1.16) | 1.08 (1.01–1.16) | 1.06 (0.96–1.18) | 0.975 |
| Women | 1 (reference) | 1.08 (0.98–1.20) | 1.13 (0.98–1.31) | 1.09 (0.90–1.34) | 1.04 (0.77–1.41) | |
| Obesity, kg/m2 | ||||||
| <25 | 1 (reference) | 1.08 (1.02–1.13) | 1.10 (1.04–1.17) | 1.07 (0.99–1.16) | 1.06 (0.95–1.19) | 0.958 |
| ≥25 | 1 (reference) | 1.11 (1.04–1.19) | 1.11 (1.02–1.20) | 1.13 (1.02–1.24) | 1.10 (0.97–1.25) | |
| Smoking | ||||||
| No | 1 (reference) | 1.08 (1.02–1.14) | 1.05 (0.98–1.12) | 1.07 (0.99–1.16) | 1.00 (0.89–1.12) | 0.050 |
| Current | 1 (reference) | 1.12 (1.05–1.20) | 1.17 (1.09–1.27) | 1.12 (1.01–1.23) | 1.13 (0.99–1.30) | |
Hazard ratios (95% confidence intervals) were calculated using a multivariable Cox hazard regression analysis after adjusting for age, sex, smoking status, alcohol drinking, regular exercise, and body mass index.
IFG, impaired fasting glucose; MI, myocardial infarction.