Table 2.
Incidence of Cardiovascular Disease or Mortality According to BMI
| BMI, kg/m2 | Event | FU duration, PY | Incidence,/1,000 PY | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
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| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |||||
| Premenopausal women | ||||||||||
| MI | <18.5 | 136 | 264,101 | 0.51 | 0.983 (0.827–1.169) | 0.850 | 1.057 (0.889–1.257) | 0.528 | 1.055 (0.888–1.254) | 0.543 |
| 18.5–22.9 | 2,438 | 4,647,249 | 0.52 | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| 23.0–24.9 | 1,457 | 2,217,425 | 0.66 | 1.252 (1.173–1.336) | <0.001 | 1.150 (1.078– 1.228) | <0.001 | 1.144 (1.071–1.221) | <0.001 | |
| 25.0–29.9 | 1,672 | 2,052,721 | 0.81 | 1.552 (1.458–1.652) | <0.001 | 1.333 (1.250–1.421) | <0.001 | 1.306 (1.225–1.393) | <0.001 | |
| ≥30.0 | 310 | 293,966 | 1.05 | 2.012 (1.787–2.264) | <0.001 | 1.616 (1.431–1.824) | <0.001 | 1.522 (1.347–1.717) | <0.001 | |
| Stroke | <18.5 | 127 | 264,019 | 0.48 | 0.889 (0.744–1.062) | 0.196 | 0.991 (0.829–1.184) | 0.917 | 0.990 (0.828–1.183) | 0.912 |
| 18.5–22.9 | 2,516 | 4,645,957 | 0.54 | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| 23.0–24.9 | 1,646 | 2,216,041 | 0.74 | 1.371 (1.289–1.459) | <0.001 | 1.199 (1.126–1.276) | <0.001 | 1.189 (1.117–1.266) | <0.001 | |
| 25.0–29.9 | 1,936 | 2,050,768 | 0.94 | 1.743 (1.643–1.849) | <0.001 | 1.348 (1.268–1.433) | <0.001 | 1.312 (1.234–1.396) | <0.001 | |
| ≥30.0 | 373 | 293,647 | 1.27 | 2.347 (2.105–2.616) | <0.001 | 1.575 (1.408–1.762) | <0.001 | 1.456 (1.304–1.633) | <0.001 | |
| Mortality | <18.5 | 285 | 264,490 | 1.08 | 1.416 (1.255–1.598) | <0.001 | 1.511 (1.339–1.706) | <0.001 | 1.477 (1.309–1.667) | <0.001 |
| 18.5–22.9 | 3,544 | 4,655,073 | 0.76 | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| 23.0–24.9 | 1,769 | 2,222,361 | 0.80 | 1.045 (0.987–1.107) | 0.128 | 0.964 (0.910–1.021) | 0.211 | 0.959 (0.906–1.016) | 0.155 | |
| 25.0–29.9 | 1,851 | 2,058,436 | 0.90 | 1.181 (1.116–1.249) | <0.001 | 1.017 (0.96–1.078) | 0.568 | 0.999 (0.942–1.058) | 0.966 | |
| ≥30.0 | 377 | 295,109 | 1.28 | 1.678 (1.509–1.866) | <0.001 | 1.345 (1.206–1.499) | <0.001 | 1.247 (1.118–1.392) | <0.001 | |
|
| ||||||||||
| Postmenopausal women | ||||||||||
| MI | <18.5 | 344 | 186,154 | 1.85 | 1.206 (1.082–1.345) | 0.001 | 1.185 (1.063–1.322) | 0.002 | 1.195 (1.072–1.332) | 0.001 |
| 18.5–22.9 | 5,790 | 3,765,114 | 1.54 | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| 23.0–24.9 | 5,365 | 2,962,639 | 1.81 | 1.176 (1.133–1.221) | <0.001 | 1.060 (1.021–1.100) | 0.002 | 1.054 (1.015–1.094) | 0.006 | |
| 25.0–29.9 | 8,384 | 3,622,904 | 2.31 | 1.502 (1.452–1.553) | <0.001 | 1.219 (1.178–1.262) | <0.001 | 1.196 (1.156–1.238) | <0.001 | |
| ≥30.0 | 1,419 | 477,508 | 2.97 | 1.931 (1.822–2.046) | <0.001 | 1.442 (1.359–1.53) | <0.001 | 1.353 (1.275–1.436) | <0.001 | |
| Stroke | <18.5 | 496 | 185,376 | 2.68 | 1.169 (1.068–1.28) | 0.001 | 1.149 (1.05–1.258) | 0.003 | 1.165 (1.064–1.275) | 0.001 |
| 18.5–22.9 | 8,600 | 3,752,445 | 2.29 | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| 23.0–24.9 | 7,948 | 2,950,158 | 2.69 | 1.175 (1.14–1.212) | <0.001 | 1.022 (0.991–1.054) | 0.166 | 1.015 (0.984–1.046) | 0.357 | |
| 25.0–29.9 | 11,816 | 3,606,588 | 3.28 | 1.430 (1.391–1.47) | <0.001 | 1.080 (1.049–1.111) | <0.001 | 1.055 (1.026–1.086) | <0.001 | |
| ≥30.0 | 1,991 | 474,810 | 4.19 | 1.832 (1.744–1.923) | <0.001 | 1.239 (1.179–1.302) | <0.001 | 1.152 (1.096–1.211) | <0.001 | |
| Mortality | <18.5 | 1,150 | 187,083 | 6.15 | 2.018 (1.899–2.144) | <0.001 | 1.872 (1.761–1.989) | <0.001 | 1.835 (1.727–1.950) | <0.001 |
| 18.5–22.9 | 11,568 | 3,784,473 | 3.06 | 1 (reference) | 1 (reference) | 1 (reference) | ||||
| 23.0–24.9 | 8,504 | 2,981,041 | 2.85 | 0.932 (0.907–0.959) | <0.001 | 0.837 (0.814–0.861) | <0.001 | 0.839 (0.816–0.863) | <0.001 | |
| 25.0–29.9 | 12,075 | 3,653,037 | 3.31 | 1.080 (1.052–1.107) | <0.001 | 0.864 (0.842–0.887) | <0.001 | 0.856 (0.834–0.879) | <0.001 | |
| ≥30.0 | 2,178 | 482,572 | 4.51 | 1.475 (1.409–1.544) | <0.001 | 1.094 (1.045–1.147) | <0.001 | 1.029 (0.982–1.079) | 0.226 | |
Model 1: without adjustment; Model 2: with adjustment for age, smoking, drinking history, low income, regular exercise, hormone replacement therapy (in the case of postmenopausal women), hypertension, dyslipidemia, and estimated glomerular filtration rate <60 mL/min/1.73 m2; Model 3: with adjustment for diabetes mellitus in addition to Model 2.
BMI, body mass index; FU, follow-up; PY, person-year; HR, hazard ratio; CI, confidence interval; MI, myocardial infarction.