Table 1.
Patient demographics and clinical characteristics
| Variable | Overall | 1990–1999 | 2000–2009 | 2010–2016 | P-value | |
|---|---|---|---|---|---|---|
| Patient | 212 | 75 | 73 | 64 | ||
| Male sex | 121 (57.1) | 48 (64.0) | 42 (57.5) | 31 (48.4) | 0.1825 | |
| Age at ulcerative colitis diagnosis (yr)a | ||||||
| (n = 209) | 28 (22–42) | 27 (22–43) | 29 (22–39) | 29 (22–42) | 0.9858 | |
| Disease duration before colectomy (mo)a | ||||||
| (n = 208) | 40 (11–100) | 44 (16–93) | 45 (12–106) | 32 (5–93) | 0.3454 | |
| Disease extent (n = 196) | 0.0309 | |||||
| E1 | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||
| E2 | 37 (17.5) | 16 (21.3) | 16 (21.9) | 5 (7.8) | ||
| E3 | 159 (75.0) | 52 (69.3) | 50 (68.5) | 57 (89.1) | ||
| Unknown | 16 (7.5) | 7 (9.3) | 7 (9.6) | 2 (3.1) | ||
| Primary sclerosing cholangitis | 9/208 (4.3) | 5/74 (6.8) | 4/70 (5.7) | 0/64 (0) | 0.119 | |
| Other extraintestinal manifestation | 36/165 (21.8) | 18/69 (26.1) | 13/59 (22.0) | 5/37 (13.5) | 0.3314 | |
| Depression | 12/185 (6.5) | 0/52 (0) | 6/69 (8.7) | 6/64 (9.4) | 0.0809 | |
| Prior appendicectomy | 11/210 (5.2) | 3/74 (4.1) | 5/72 (6.9) | 3/64 (4.7) | 0.7182 | |
| Family history of inflammatory bowel disease | 40/158 (25.3) | 13/57 (22.8) | 11/61 (18.0) | 16/40 (40.0) | 0.0393 | |
| Body mass index (kg/m2)a (n = 154) | 23.4 (20.9–27.3) | 22.5 (19.2–25.6) | 24.3 (21.7–27.8) | 23.6 (21.4–27.4) | 0.0887 | |
| Smoking (n = 185) | 0.4419 | |||||
| Never | 89 (42.0) | 28 (37.3) | 28 (38.4) | 33 (51.6) | ||
| Current | 18 (8.5) | 7 (9.3) | 6 (8.2) | 5 (7.8) | ||
| Ex-smoker | 78 (36.8) | 28 (37.3) | 29 (39.7) | 21 (32.8) | ||
| Unknown | 27 (12.7) | 12 (16.0) | 10 (13.7) | 5 (7.8) | ||
| Systemic corticosteroids > 20 mg within 7 days | ||||||
| Before colectomy | 110/178 (61.8) | 30/53 (56.6) | 40/65 (61.5) | 40/60 (66.7) | 0.5506 | |
| Before IPAA | 13/190 (6.8) | 9/54 (16.7) | 4/72 (5.6) | 0/64 (0) | 0.0013 | |
| Thiopurine within 30 days of colectomy | 64/184 (34.8) | 10/57 (17.5) | 25/65 (38.5) | 29/62 (46.8) | 0.0025 | |
| Cyclosporin within 30 days of colectomy | 27/204 (13.2) | 3/75 (4.0) | 19/67 (28.4) | 5/62 (8.1) | 0.00003 | |
| Anti-TNF exposure within 30 days of colectomy | 36/206 (17.5) | 0/75 (0) | 7/68 (10.3) | 29/63 (46.0) | < 0.00001 | |
| Hemoglobinb (g/L) | ||||||
| Before colectomy (n = 180) | 118 (103–131) | 122 (66–158) | 117 (77–160) | 115 (79–166) | 0.1872 | |
| Before IPAA (n = 189) | 133 (124–145) | 130 (99–162) | 133 (79–166) | 137 (116–171) | 0.0851 | |
| Albuminb (g/L) | ||||||
| Before colectomy (n = 178) | 33 (26–40) | 36 (11–49) | 33 (15–46) | 30 (15–50) | 0.0016 | |
| Before IPAA (n = 186) | 41 (38–44) | 41 (30–49) | 40 (29–50) | 41 (32–48) | 0.4511 | |
Values are presented as number only, number (%), amedian (interquartile range), or bmean (range).
E1, ulcerative proctitis; E2, left-sided ulcerative colitis (UC); E3, extensive UC; IPAA, ileal pouch-anal anastomosis; TNF, tumor necrosis factor.