Table 4.
Univariate analysis for IPAA leak, pouch fistula, and pouch failure as well as multivariate model for pouch failure
| Factor | Univariate analysis |
Multivariable analysis |
|||
|---|---|---|---|---|---|
| Anastomotic leak | Pouch fistula | Pouch failure | Pouch failure | ||
| Sex, female vs. male | 1.60 (0.52–4.93) | 1.52 (0.69–3.36) | 0.65 (0.16–2.68) | ||
| Age (yr), ≤ 30 vs. > 30 | 1.89 (0.50–7.09) | 0.37 (0.16–0.82) | 1.11 (0.27–4.57) | ||
| Body mass index (kg/m2), ≤ 18.1 vs. > 18.1 | 0.15 (0.04–0.58) | 0.65 (0.17–2.55) | 0.72 (0.08–6.46) | ||
| Disease extent, E2 vs. E3 | 3.02 (0.38–23.97) | 0.74 (0.27–2.00) | 1.84 (0.22–15.23) | ||
| Steroids > 20 mg/day within 7 days, yes vs. no | |||||
| Before colectomy | 7.44 (0.94–59.02) | 3.70 (1.20–11.40) | Inf (NaN–Inf) | 1.03 (0.96–1.09) | |
| Before pouch surgery | 3.04 (0.59–15.59) | 1.12 (0.23–5.42) | 5.00 (0.89–28.02) | 1.06 (0.93–1.20) | |
| Cyclosporin within 30 days before surgery, yes vs. no | 2.10 (0.54–8.18) | 1.62 (0.55–4.78) | 0.93 (0.11–7.92) | ||
| Anti-TNF within 30 days before surgery, yes vs. no | Inf (NaN–Inf) | 2.62 (0.33–21.03) | 0.76 (0.09–6.82) | ||
| Acute indication, yes vs. no | 2.51 (0.75–8.43) | 4.05 (1.64–9.99) | 4.15 (0.84–20.53) | ||
| Surgery stage, 2 vs. 3 | 1.46 (0.39–5.53) | 0.74 (0.31–1.73) | 1.36 (0.27–6.99) | ||
| IPAA anastomosis, hand-sewn vs. stapled | Inf (NaN–Inf) | Inf (NaN–Inf) | 1.19 (0.14–10.00) | ||
| Anastomotic leak | NA | 4.14 (1.25–13.71) | 8.35 (1.82–38.40) | 1.19 (1.06–1.33) | |
| Pouch fistula | NA | NA | 14.09 (3.29–60.44) | 1.20 (1.10–1.31) | |
Values are presented as odds ratio (95% confidence interval).
E2, left-sided ulcerative colitis (UC); E3, extensive UC; NaN, not a number; Inf, infinity; TNF, tumor necrosis factor; IPAA, ileal pouch-anal anastomosis, NA, not applicable.