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. 2021 Sep 23;40(44):6258–6272. doi: 10.1038/s41388-021-02018-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Design of a GPScore (Gene set prognostic scoring) algorithm for calculation of gene prognostic scores, data visualization, and analysis. SPLICEOSOMAL_SNRNP_ASSEMBLY gene set is provided as an example. b Multidimensional scaling of enriched gene sets associated with EPOR expression in NB patients. Only gene sets with prognostic scores that passed the FDR test (q value < 0.01) are marked. c Circos plot showing the number of shared gene sets calculated by GSEA for each gene pair. The width of ribbons is proportional to the number of shared enriched gene sets. d Prognostic scores for 12 enriched gene sets shared by at least 5 of 6 genes. Dot lines indicate 3 sigma interval for prognostic scores distribution for 20 randomly generated gene sets. e Kaplan–Meier survival analysis for Kocak dataset (n = 476) based on base-excision repair score (divided into quartiles from highest Q1 to lowest Q4 scores) and INSS stages. A similar analysis for NRC and Versteeg datasets is provided in Fig. S5b.