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. 2021 Sep 23;40(44):6235–6247. doi: 10.1038/s41388-021-02017-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Kaplan–Meier plot of disease-free survival of breast cancer patients (n = 2643) separated into two groups with high (blue) or low (red) mRNA expression levels of ISG15. B Kaplan-Meier plot of free disease survival of patients from A that are negative for tumour cells in lymph nodes (n = 740). C Kaplan-Meier plot of free disease survival of patients from A positive for tumour presence in lymph nodes (n = 1178). D Kaplan-Meier plot of disease-free survival association with mRNA levels of UBE2L6, separated into two groups with high (blue) or low (red) levels, in lymph node positive patients (n = 744) or lymph node negative patients (n = 350). As in D analysis of mRNA levels in lymph node positive and negative of the interferon coding genes IFNA1 (n = 600) (E) and IFNB1 (n = 744) (F). G WB analysis of the indicated representative clones to confirm the knockout, cells were treated for 48 h with either vehicle or IFNb1a 250 pM to boost the protein levels of the different ISGylation-related proteins.