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. 2021 Jun 10;48(13):4472–4482. doi: 10.1007/s00259-021-05420-1

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© The Author(s) 2021

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Fig. 2 — The three-compartment model: the red compartment C_plasma represents the tracer activity in the blood. Compartment C1 (middle octagon) represents unspecific bound and free tracer parts in the tissue. K₁ is the transport rate of the tracer from the blood into the tissue. k₂ correspondingly stands for the backward path, or efflux. The C2 compartment (right octagon) stands for PSMA-bound and clathrin-mediated internalised tracer components. K₃ measures the receptor binding and internalisation rate and k₄ in turn measures the externalisation rate. The unit of measurement for all K values is 1/min in each case