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. 2021 Jun 10;48(13):4472–4482. doi: 10.1007/s00259-021-05420-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Dynamic PET-CT of a BCR (PSA 2.47 ng/mL) after radiation and hormone therapy with local recurrence (arrow) and bone metastasis (arrow). Top left: Fused coronary PET-CT image showing the local recurrence and bone metastasis in the os ilium 60 min p.i.. Top right: Mean time-activity curves in the local recurrence (top diagram) and the bone metastasis (bottom diagram) compared to the vascular activity in each case. Bottom row: Coronary PET images in time sequence from frame 1 (30 s after injection) to frame 24 (60 min after injection). Frame 5 (= 2.5 min p.i.) already shows accumulation in the local recurrence and bone metastasis, without bladder activity being visible. Frame 12 (= 7 min p.i.) shows increasing activity in all lesions and at the same time activity now appears in the bladder. Frame 24 (= after 60 min) shows strong activity in the bladder adjacent to the local recurrence which is barely increasing in activity