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. 2021 Nov 3;12:6354. doi: 10.1038/s41467-021-26677-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Montage of live-cell confocal microscopic images of 393P cells that have ectopic expression of ZEB1 or empty vector and were treated with pHRodo Green-tagged Tfn. Gains in signal intensity over time (red arrows) mark vesicles that have reduced intravesicular pH and enhanced maturation. Scale bars, 10 µm. b, c Quantification of pHRodo Green-tagged Tfn signal intensities following ZEB1 gain-of-function (b) or ZEB1 loss-of-function (c). Signal intensities in each cell (dot) determined at each time point after pHRodo Green-tagged Tfn treatment initiation. n = 8 cells from 4 independent experiments. P values, two-way ANOVA.