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. 2021 Nov 3;11:21562. doi: 10.1038/s41598-021-00882-7

Table 1.

General characteristics of participants.

Characteristics Total participants P value
Thyroid cancer Control
Age group (years old, n, %) 1.000
 45–49 520 (11.2) 2080 (11.2)
 50–54 1335 (28.8) 5340 (28.8)
 55–59 1142 (24.7) 4568 (24.7)
 60–64 776 (16.8) 3104 (16.8)
 65–69 475 (10.3) 1900 (10.3)
 70–74 277 (6.0) 1108 (6.0)
 75–79 83 (1.8) 332 (1.8)
 80–84 23 (0.5) 92 (0.5)
 ≥ 85 1 (0.0) 4 (0.0)
Sex (n, %) 1.000
 Male 993 (21.4) 3972 (21.4)
 Female 3639 (78.6) 14,556 (78.6)
Income (n, %) 1.000
 1 (lowest) 604 (13.0) 2416 (13.0)
 2 515 (11.1) 2060 (11.1)
 3 733 (15.8) 2932 (15.8)
 4 959 (20.7) 3836 (20.7)
 5 (highest) 1821 (39.3) 7284 (39.3)
Region of residence (n, %) 1.000
 Urban 2216 (47.8) 8864 (47.8)
 Rural 2416 (52.2) 9664 (52.2)
Obesity (BMI, kg/m2, n, %)  < 0.001*
 < 18.5 (underweight) 64 (1.4) 393 (2.1)
 ≥ 18.5 to < 23 (normal) 1524 (32.9) 6911 (37.3)
 ≥ 23 to < 25 (overweight) 1315 (28.4) 5016 (27.1)
 ≥ 25 to < 30 (obese I) 1533 (33.1) 5613 (30.3)
 ≥ 30 (obese II) 196 (4.2) 595 (3.2)
Smoking status (n, %)  < 0.001*
 Nonsmoker 4030 (87.0) 15,785 (85.2)
 Past smoker 348 (7.5) 1145 (6.2)
 Current smoker 254 (5.5) 1598 (8.6)
Alcohol consumption (n, %) 0.008*
 < 1 time a week 3515 (75.9) 14,398 (77.7)
 ≥ 1 time a week 1117 (24.1) 4130 (22.3)
Charlson comorbidity index (n, %)  < 0.001*
 0 2882 (62.2) 14,597 (78.8)
 1 755 (16.3) 2155 (11.6)
 2 279 (6.0) 903 (4.9)
 3 105 (2.3) 397 (2.1)
 ≥ 4 611 (13.2) 476 (2.6)
Total cholesterol (mg/dL, mean, SD) 199.4 (37.8) 202.1 (37.6)  < 0.001*
 SBP (mmHg, mean, SD) 124.1 (15.5) 123.3 (15.6) 0.003*
 DBP (mmHg, mean, SD) 77.2 (10.2) 76.6 (10.2) 0.001*
 Fasting blood glucose (mg/dL, mean, SD) 98.5 (24.8) 0.061
Meteorological and air pollution data (mean, SD)
Mean temperature for 3 years (1095 days) (°C) 12.9 (1.2) 12.9 (1.2) 0.005*
Highest temperature for 3 years (1095 days) (°C) 18.0 (1.1) 18.0 (1.1) 0.008*
Lowest temperature for 3 years (1095 days) (°C) 8.6 (1.6) 8.5 (1.7) 0.022*
Temperature range for 3 years (1095 days) (°C) 9.4 (1.4) 9.4 (1.4) 0.556
Relative humidity for 3 years (1095 days) (%) 65.5 (4.6) 65.5 (4.4) 0.424
Ambient atmospheric pressure for 3 years (1095 days) (hPa) 1006.4 (4.0) 1006.1 (4.4)  < 0.001*
Sunshine duration for 3 years (1095 days) (hr) 5.8 (0.4) 5.8 (0.3) 0.003*
Rainfall for 3 years (1095 days) (mm) 8.7 (0.9) 8.6 (0.9) 0.019*
SO2 for 3 years (1095 days) (ppb) 5.3 (1.0) 5.3 (1.0) 0.073
NO2 for 3 years (1095 days) (ppb) 24.1 (8.7) 24.2 (8.7) 0.495
O3 for 3 years (1095 days) (ppb) 23.7 (4.6) 23.4 (4.5) 0.001*
CO for 3 years (1095 days) (ppb) 525.4 (80.0) 530.7 (80.6)  < 0.001*
PM10 for 3 years (1095 days) (μg/m3) 51.9 (6.4) 52.7 (6.5)  < 0.001*

BMI body mass index (kg/m2); ppb parts per billion; SD standard deviation.

*Chi-square test or independent t test. Significance at P < 0.05.