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. 2021 Nov 3;7:331. doi: 10.1038/s41420-021-00663-1

Fig. 4. Simulation of the development trajectory of malignant cells and the analysis of gene expression pattern inferred by Monocle2.

Fig. 4

Simulation of the differentiation trajectory of malignant cells group from PDAC, A pseudo-trajectory of malignant cells, B cell type transition, C cell source transition. D Pseudotime trajectory of malignant cells from different cells. Each point corresponds to a single cell. E Expression of representative genes (EPCAM, KRT19, MUC1, and CEACAM6) are mapped to the single-cell trajectory plot. Color key from gray to red indicates relative expression levels from low to high. F Heatmap showing expression of representative known PDAC associated genes across single cells. Corresponding pathways for each gene were also shown. Color key from blue to red indicates relative expression levels from low to high. G Heatmap showing expression of representative identified TFs across single cells. Color key from blue to red indicates relative expression levels from low to high.