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. 2021 Nov 3;7:331. doi: 10.1038/s41420-021-00663-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Heatmap hierarchical clustering showing differentially expressed transcription factor genes along with the pseudotime curve. Color key from blue to red indicates relative expression levels from low to high. B Expression patterns of representative differentially expressed genes in the progression process. C The pseudotime heatmap displayed the differentially expressed genes between the branches according to the BEAM analysis. Color key from blue to red indicates relative expression levels from low to high. D Expression patterns of representative differentially expressed genes between different branches in the progression process.