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. 2021 Nov 3;7:331. doi: 10.1038/s41420-021-00663-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A The heatmap exhibits the average regulon activities of transcription factors in different cellular types, color key from blue to red indicates relative expression levels from low to high. B Heatmap of regulon activity analyzed by SCENIC with default thresholds for binarization. The “regulon” refers to regulatory network of TFs and their target genes. “On” indicates active regulons; “Off” indicates inactive regulons. C The t-SNE plot shows the top four highly expressed transcription factors in type 5 ductal cells, and part of their motifs were listed in the right panel. D Violin plots showing distributions of representative TFs expression among different cell types.