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. 2021 Nov 4;2(12):100456. doi: 10.1016/j.xcrm.2021.100456

Figure 3.

Figure 3

Human placenta PCS responses following SARS-CoV-2 infection

(A) LDH release in placenta PCSs exposed to 5 × 105 PFU of SARS-CoV-2 120 h p.i. Each symbol represents an individual donor (n = 6).

(B and C) Induction of pro-inflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor [TNF], and interferon [IFN]-γ-induced protein 10 kDa/C-X-C motif chemokine ligand 10 [IP-10/CXCL10]) (B), and (C) IFN (β, λs) transcripts in placenta PCSs 120 h p.i. with mock (empty symbols) or 5 × 105 PFU of SARS-CoV-2 (solid symbols). Boxplots indicate the median value (centerline) and interquartile ranges (box edges), with whiskers extending to the lowest and the highest values. Each symbol represents an individual donor (n = 7). A 2-sided unpaired t test was applied to compare infected to mock control groups.