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. 2021 Nov 3;12:6323. doi: 10.1038/s41467-021-26582-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Annotation of cell populations in mutant HSPCs. The cell state for each cell from E2-KO, G12D, or G12D/E2-KO mutant HSPCs was annotated based on the cell state of their nearest neighbor in WT HSPCs. The differentially expressed genes (DEGs) between WT and mutant HSPCs within the same cell state (within states) or between states within the same genotype (between states) were identified by Wilcoxon rank sum test (adjusted P value < 0.01). b Number of DEGs within and between cell states. Histograms show the numbers of DEGs between WT and mutant HSPCs within each cell state (red) or between different cell states (blue). c KNN visualization of all single cells by combining 12 samples. Each dot represents a single cell. Cells are colored by cell-type annotations. d KNN visualization of single cells from each sample. Each plot shows cells from the indicated genotype and time point (red) against all cells from other genotypes and time points (gray). e Violin plot is shown for Ezh2 mRNA expression in WT or mutant HSPCs at different time points (T1–T3).